Respiratory Syncytial Virus: Virology, Reverse Genetics, and ...
Human respiratory syncytial virus (RSV) is an enveloped, nonsegmented negative-strand RNA virus of family Paramyxoviridae. RSV is the most complex member of the family in terms of the number of genes and proteins. It is also relatively divergent and distinct from the prototype members of the family.
Structure and function of respiratory syncytial virus surface ...
In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.
Respiratory syncytial virus: from pathogenesis to potential …
In this review, we briefly describe the structure of RSV virions, the latest progress in understanding host surface virus-binding receptors and the viral life cycle. Then, we discuss recent advances in understanding the pathogenesis of RSV infection.
Structural Analysis of Respiratory Syncytial Virus Reveals the …
RSV and human metapneumovirus (HMPV) are grouped together in the Paramyxoviridae subfamily Pneumovirinae based on their sequence homology, protein activity, and morphology. The RSV genome consists of 10 open reading frames (ORFs) that encode 11 structural and nonstructural proteins (10).
Structural landscape of the respiratory syncytial virus ... - Nature
2023年9月15日 · We explore the polymorphism of the nucleocapsid-like assemblies, report five structures of the full-length particles and two alternative arrangements formed by a C-terminally truncated...
The 24-Angstrom Structure of Respiratory Syncytial Virus …
2007年6月13日 · Respiratory syncytial virus (RSV), a nonsegmented, negative-sense RNA-containing virus, is a common cause of lower respiratory tract disease.
Structure and Function of Respiratory Syncytial Virus Surface ...
2013年12月21日 · In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development. These keywords were added by machine and not by the authors.
Structural Insights into the Respiratory Syncytial Virus RNA
2021年5月5日 · RNA synthesis in respiratory syncytial virus (RSV), a negative-sense (-) nonsegmented RNA virus, consists of viral gene transcription and genome replication. Gene transcription includes the positive-sense (+) viral mRNA synthesis, 5'-RNA capping and methylation, and 3' end polyadenylation.
Respiratory Syncytial Virus - SARS, MERS and other Viral Lung ...
2016年6月1日 · Viral Structure and Proteins. RSV particles are pleomorphic with both spherical and filamentous particles of different sizes . The virions display three surface proteins: F, G and SH (small hydrophobic) .
A Contemporary View of Respiratory Syncytial Virus (RSV) …
The genomic organization and virion structure of respiratory syncytial virus (RSV) strain A2 are shown with each of the 10 genes color-coded based on their relative functions: Immunomodulatory (light blue), envelope structure (green), surface structures for attachment and entry (red), and replication and genomic stability (dark blue).
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