What are PARP inhibitors? - MD Anderson Cancer Center
2024年4月3日 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) polymerase, which is a protein in cells that helps repair damaged DNA.
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and …
2020年9月9日 · PARP inhibitors (PARPi) were the first approved cancer drugs that specifically targeted the DNA damage response in BRCA1/2 mutated breast and ovarian cancers.
PARP Inhibitors | Targeted cancer drugs | Cancer Research UK
2024年9月24日 · How do PARP inhibitors work? PARP is a protein (enzyme) found in our cells, it stands for poly-ADP ribose polymerase. It helps damaged cells to repair themselves. As a cancer treatment, PARP inhibitors stop the PARP from doing its …
List of PARP inhibitors (Poly (ADP-ribose) polymerase inhibitors ...
2023年4月14日 · Poly (ADP-ribose) polymerase inhibitors, also called PARP inhibitors, are targeted therapies that are used to treat cancer. PARP is a protein that has a role in cellular growth, regulation, and cell repair and it helps cancer cells repair themselves and survive.
PARP and PARG inhibitors in cancer treatment - PMC
Poly (ADP-ribose) polymerase (PARP) inhibitors represent a successful example of precision medicine as the first drugs targeting DNA damage response to have entered the clinic. PARP inhibitors act through synthetic lethality with mutations in DNA repair genes and were approved for the treatment of BRCA mutated ovarian and breast cancer.
PARP inhibitors: its role in treatment of cancer - PMC
Poly (ADP-ribose) polymerase 1 (PARP1) is an important protein in the base excision repair (BER) pathway for DNA single strand breaks (SSBs). This makes PARP1 an interesting target for cancer therapy. Currently there are eight PARP inhibitors …
PARP Inhibitors for Prostate Cancer - WebMD
2024年5月27日 · PARP inhibitors are a new kind of prostate cancer treatment called a targeted therapy. The goal of targeted therapy is to kill cancer cells without harming healthy cells. Unlike chemotherapy and...
The role of PARP in DNA repair and its therapeutic exploitation
Of the known DNA repair inhibitors, Poly (ADP-ribose) polymerase inhibitors (PARPi) are furthest along in development and appear promising in a variety of cancer types, including breast and ovarian cancers.
Poly(ADP-ribose) polymerase inhibition: past, present and future
2020年9月3日 · This Review provides a timeline of PARP biology and medicinal chemistry, summarizes the pathophysiological processes in which PARP plays a role and highlights key opportunities and challenges...
Review of poly (ADP-ribose) polymerase (PARP) mechanisms of …
Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. PARPs play an important role in various cellular processes, including modulation of chromatin structure, transcription, replication, recombination, and DNA repair.
- 某些结果已被删除一些您可能无法访问的结果已被隐去。显示无法访问的结果