The role of m6A modification in the biological functions and …
2021年2月21日 · In this review, we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems.
The role of m6A modification in physiology and disease - Nature
2020年11月8日 · N6-methyladenosine (m 6 A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) proteins, and is recognized by...
The detection and functions of RNA modification m6A based on m6A …
N6-methyladenosine (m6A) is the most frequent chemical modification in eukaryotic mRNA and is known to participate in a variety of physiological processes, including cancer progression and viral infection. The reversible and dynamic m6A modification ...
Decoding the interplay between m6A modification and stress …
2024年11月15日 · Here, we presented a spatiotemporal m 6 A imaging system (SMIS) that can monitor the m 6 A modification and the translation of mRNAs with high specificity and sensitivity in a single live cell.
The role of m6A modification in the biological functions and ... - PubMed
2021年2月21日 · N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIR …
Dynamic regulation and functions of mRNA m6A modification
2022年1月29日 · Here, we review the general role of m6A, highlighting recent advances related to the three major types enzymes that determine the level of m6A modification (i.e., writers, erasers, and readers) and the regulatory mechanism by which m6A influences multiple stages of …
The Emerging Role of m6A Modification in Regulating the …
In this review, we focus on the important role of m6A modification in biological functions and highlight its contributions to immune cells and the development of autoimmune diseases, thereby providing promising epitranscriptomic targets for preventing and treating autoimmune disorders.
m6A Modification in Coding and Non-coding RNAs: Roles and …
N6-methyladenosine (m6A) RNA modification emerges in recent years as a new layer of regulatory mechanism controlling gene expression in eukaryotes. As a reversible epigenetic modification found not only in messenger RNAs (mRNAs), but also in ...
The role of N-methyladenosine modification in acute and
2023年12月8日 · N6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in adenosine in RNA, which can occur in various RNAs such as mRNAs, lncRNAs and miRNAs.
m6A Modification: A Double-Edged Sword in Tumor Development
2021年7月26日 · Herein, we briefly introduce m6A modification regulators and describe in detail how m6A methylation functions as a double-edged sword to participate in the initiation and development of numerous tumors and the prospects of m6A modification as an important diagnostic biomarker and therapeutic target for tumor treatment.
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