Cellular Senescence - Definition, Causes and Effects - Biology …
2017年5月26日 · Cellular senescence is a state in which cells can no longer divide. This permanent state entails benefits and detriments for the organism in which the cells live. Whereas cellular senescence was first attributed to tumor suppression and aging, more recent research has found that it also promotes cancer and tissue repair.
Cellular senescence: the good, the bad and the unknown
2022年8月3日 · Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged senescence can be maladaptive, leading to...
Cellular senescence in ageing: from mechanisms to therapeutic ... - Nature
2020年12月16日 · Senescent cell extrinsic activities, broadly related to the activation of a senescence-associated secretory phenotype, amplify the impact of cell-intrinsic proliferative arrest and contribute...
Cellular senescence in normal physiology | Science - AAAS
2024年6月20日 · Cellular senescence, when cells become irreversibly growth arrested after a period of in vitro cell proliferation or in response to sublethal stress or oncogene expression (1, 2), plays a role in aging phenotypes and age-associated diseases (1).
Cellular Senescence: Defining a Path Forward - Cell Press
Cellular senescence is a cell state triggered by stressful insults and certain physiological processes, characterized by a prolonged and generally irreversible cell-cycle arrest with secretory features, macromolecular damage, and altered metabolism (Figure 1).
Cellular senescence: Current Biology - Cell Press
2022年5月23日 · Cell senescence acts as a potent tumour-suppressive mechanism limiting the proliferation of cells at risk of malignant transformation and supports the repair of acute tissue damage, but also represents a key driver of ageing and age-related diseases.
Cellular Senescence: Defining a Path Forward - ScienceDirect
2019年10月31日 · Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly.
Mechanisms and Regulation of Cellular Senescence - PMC
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotype.
Cellular senescence in aging and age-related disease: from …
Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related disease, and it is an attractive target for therapeutic exploitation.
The role of senescent cells in ageing - PMC - PubMed Central (PMC)
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, …
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