Molecular Characteristics of Amyloid Precursor Protein (APP) …
Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals.
Amyloid-beta precursor protein - Wikipedia
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [5] and has been implicated as a regulator of synapse formation, [6] neural plasticity, [7] antimicrobial activity, [8] and iron export. [9]
Amyloid Precursor Protein and Alzheimer’s Disease - PMC
Amyloid precursor protein (APP) is a membrane protein considered to play a main role in AD pathology. It is known that APP in physiological conditions follows a non-amyloidogenic pathway; however, it can proceed to an amyloidogenic scenario, which leads to the generation of extracellular deleterious Aβ plaques.
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · The Aβ is a 4 kDa fragment of the amyloid precursor protein (APP), a larger precursor molecule widely produced by brain neurons, vascular and blood cells (including platelets), and, to a lesser...
Amyloid Precursor Protein - an overview | ScienceDirect Topics
Amyloid precursor protein (APP) is a transmembrane protein that is synthesized in the endoplasmic reticulum and plays a major role in synaptic development, mineral transfer, neuronal plasticity, and regulation of cell signaling in neuronal tissues.
Cellular Functions of the Amyloid Precursor Protein from …
Amyloid precursor protein (APP) is a key player in Alzheimer’s disease (AD). The Aβ fragments of APP are the major constituent of AD-associated amyloid plaques, and mutations or duplications of the gene coding for APP can cause familial AD.
The amyloid precursor protein: beyond amyloid - PMC
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD).
Not just amyloid: physiological functions of the amyloid precursor ...
2017年3月31日 · Amyloid precursor protein (APP) has been heavily implicated in Alzheimer disease, but the physiological roles of APP and the related APP-like proteins (APLPs) remain less well understood.
Amyloid precursor protein and its interacting proteins in ...
2023年8月31日 · Amyloid precursor protein (APP) is a key molecule in the pathogenesis of Alzheimer's disease (AD) as the pathogenic amyloid-β peptide is derived from it. Two closely related APP family proteins (APPs) have also been identified in mammals.
Amyloid precursor protein processing and Alzheimer's disease
Genetic, biochemical, and behavioral research suggest that physiologic generation of the neurotoxic Aβ peptide from sequential amyloid precursor protein (APP) proteolysis is the crucial step in the development of AD.