Report: The Single-cell and Spatial Playbook 2024
ABOUT US CONTACT ADVERTISE PRIVACY POLICY Front Line Genomics Limited is registered in England and Wales. Company Number 10421716, VAT: GB 297 742 548. Registered Office: Ground Floor, Cromwell House, 15 …
Sample Preparation for NGS – A Comprehensive Guide
2024年8月21日 · Common challenges in sample preparation. Challenge 1: Many samples are extracted from a limited number of cells – or even a single cell.These don’t provide enough genetic material alone and so need to undergo PCR. However, this amplification step is prone to introducing bias to the sample.
What is multiplex PCR? - Front Line Genomics
2021年7月26日 · The polymerase chain reaction (PCR) is a well-established amplification technique that is widely used to rapidly make millions of copies of a specific DNA sample. It was developed by Kary Mullis in the 1980’s and is based on the ability of DNA polymerase to synthesize a new strand of complementary DNA from a template strand.
How to: perform polygenic risk score analysis
2023年7月17日 · A recent article highlights key issues related to polygenic risk score analyses and provides a starting point and reference guide for researchers.
Long-read sequencing vs short-read sequencing
2021年7月26日 · Join David Smith (Mayo Clinic), Shawn Baker (SanDiegOmics) and Tiffany Boughtwood (Australian Genomics) as they discuss how the upcoming shifts within the NGS market could affect genomics research in the future and what impact it may have on healthcare around the world: Exploring the Current Sequencing …
How-to: perform a genome-wide association study (GWAS)
2024年9月10日 · Genome-wide association studies are commonly used in the genomics world to identify variants associated with a trait or disease.During a GWAS, researchers will identify areas of the genome that show a strong signal linked to the trait in question; that is, in the discovery cohort, areas or specific markers in which variation is more common than in the controls.
Sickle Cell Disease: A 2024 Update - Front Line Genomics
2024年7月9日 · Over the last few months, including just in the last week, there have been multiple reports on new treatments for sickle cell disease. In this feature, we highlight the biggest updates in this field and think about what the future might hold.
A brief history of Next Generation Sequencing (NGS)
2021年7月26日 · Join David Smith (Mayo Clinic), Shawn Baker (SanDiegOmics) and Tiffany Boughtwood (Australian Genomics) as they discuss how the upcoming shifts within the NGS market could affect genomics research in the future and what impact it may have on healthcare around the world: Exploring the Current Sequencing Landscape The history of DNA sequencing
AI Models For Protein Structure Prediction
2024年8月14日 · Understanding how amino acid sequences translate into complex, three-dimensional structures is a problem that has been puzzling scientists for decades 1.Unlocking this mystery is key to uncovering information about how specific structures allow proteins to carry out specialised functions, opening new frontiers in synthetic biology and personalised medicine.
AlphaFold 3: Stepping into the future of structure prediction
2024年5月22日 · We’ve all heard about the potential of artificial intelligence in the life sciences field. In 2020, the launch of AlphaFold 2, pioneered by Google DeepMind, took the world by storm and marked a new age in protein structure prediction.