Fig 1. Targeting the nonimmune stromal compartment of the PDAC TME. A summary of the current stromal-targeting therapies in PDAC, including (a) degradation of HA in ECM with hyaluronidase; (b) ...

The present study aims to assess HIF-1α and NTBI concentrations in the biofluids of CKD cats. The objectives are as follows: (1) to evaluate the concentrations of HIF-1α in the plasma and urine ...

The following is a summary of “Survival impact of hypoxia-inducible factor-1 alpha (HIF-1α) in Nucleophosmin1 mutated acute myeloid leukemia,” published in the December 2024 issue of Hematology by ...

Credit: GSK Jesduvroq is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor. The product was discontinued for business reasons and not for any safety or effectiveness issues.

Oncology Medicinal Chemistry Worldwide Research and Development, Pfizer, Inc., 10770 Science Center Drive, La Jolla, California 92121, United States ...

It would appear that hypoxia-inducible factors (HIF)-1 and HIF-2 may be important players in the pathogenesis of this disease. However, their exact role is still not fully investigated. In this ...

HIF-1α is an independent risk factor for cognitive impairment. Additionally, for elderly patients or those with low levels of education who undergo MHD are at a higher risk of CI. Clinicians may pay ...