For fiber photometry calcium imaging, Tac1-IRES-Cre/+mice were injected with 50-100 nL AAV9-CAG-FLEX-jGCaMP7f into the PSTN (ML ±1.15 mm, AP -2.40 ∼ -2.45 mm, DV - 4.90 mm from bregma). An optic fiber ...

This study shows that demyelination results in reduced inhibition by decreasing the number of release sites for the inhibitory transmitter GABA, thus promoting epileptic activity. Importantly, the ...