阿尔茨海默病，俗称“老年痴呆”，但其影响远不止记忆力减退、思维能力下降。按照发展进程，阿尔兹海默病可分为4个阶段。示意图。重庆松山医院供图1.早期阶段：轻度认知障碍会经历轻微的记忆丧失，如忘记最近发生的事，或重复询问同样的问题。2.中期阶段：轻度至中 ...

而作为AD重要的遗传风险因素，APOE ε4也与CVD和其他类型痴呆风险增加有关。因此，以往大多数学者认为，血浆Hcy水平和APOE ε4之间可能存在协同作用。

The APOE region or locus is a segment of DNA with several genes in close apposition, including APOE. Its boundaries are not strictly defined, spanning a stretch between 0.2 and 10 Mb long. In 5’ to 3’ ...

Corder, E.H. et al. HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nature Med. 4, 1182–1184 (1998).

Of the 20,000+ human genes, none has greater influence on late-onset Alzheimer’s disease than APOE. But why do certain variants of this lipid transporter protect the brain, while others endanger it? A ...

There are three major forms of APOE protein in humans. Compared with the most common version of the protein—APOE3—the APOE4 protein increases risk and APOE2 decreases risk for Alzheimer's disease.

The study, published in Nature Medicine, also concludes that those individuals homozygous for APOE4 also develop the disease earlier than those with other variants of the APOE gene. These findings ...

As many as 40% of dementia cases worldwide may be attributable to modifiable risk factors.” A new study has reinforced these findings, suggesting that older people, even those with the APOE e4 gene, ...