By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

The multicenter OlympiA trial enrolled 1836 patients with HER2-negative breast cancer harboring a germline BRCA1/2 mutation. Patients were randomized 1:1 to receive 300 mg of oral olaparib twice daily ...

We are pleased to introduce the EMBO reports Advisory Editorial Board. Members of the Board provide scientific advice to the editors for which we are very grateful. Should you wish to contact a Board ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ATR signaling is essential in sensing and ...

For cancer-suppressor genes like BRCA1, researchers have long hypothesized that a single healthy copy could still guard against tumor development. Yet women with one harmful BRCA1 mutation are far ...

D1) Representative images showing colocalization of 53BP1, and channel separation of POLK, 53BP1, and POLK speckle overlay on POLK and 53BP1. POLK speckles detected inside the nucleus are outlined in ...