Several observations from preclinical and short-term clinical studies support a role for sildenafil in the treatment of heart failure patients. The following discussion briefly considers each of ...

Milrinone, a selective inhibitor of PDE3 in vascular smooth muscle and cardiac myocytes ... and reduce pulmonary inflammation in addition to the well-documented effects on PVR. A recently published ...

There is little, if any evidence to show that this manoeuvre has any more than a cosmetic effect—in other words, hypoxic gas effectively reduces the arterial oxygenation, without any convincing effect ...

Most organic drugs contain one acid group, usually a carboxylic acid, -COOH, or one basic primary, secondary, or tertiary amino group, NC 1-3, [3,22,27,28,29] that determines the acid-base ...