Background: Nasopharyngeal carcinoma (NPC) is a type of malignant tumors commonly found in Southeast Asia and China, with insidious onset and clinical symptoms. N6-methyladenosine (m6A) modification ...

This discovery provides insights into a key RNA modification, N6-methyladenosine (m6A), which is linked to numerous biological processes and diseases, including cancer. mRNA is a type of RNA that ...

Moreover, numerous studies have demonstrated that m6A induces cancer metabolic reprogramming by regulating the expression of core metabolic genes or by activating metabolic signaling pathways.

Researchers discovered that the mRNA modification m6A triggers rapid degradation, regulating protein production. This ...

"m6A is interesting for science because this modification is often altered in people who suffer from metabolic disorders, cancer or heart disease," explains bioinformatician Kathi Zarnack.

IFI16 facilitates the inflammatory endothelial pathophenotypes observed among individuals with PAH, according to new research ...

The m6A-related lncRNAs were identified by Pearson correlation analysis. Univariate and LASSO regression analyses were used to develop a risk model. The discrimination and predictive ability were ...

More than 66,000 Americans will be diagnosed with pancreatic cancer this year. Learn more about the disease and how PanCAN can help.

By blocking METTL3, a protein that regulates m6A RNA modification, the researchers were able to promote cancer cell differentiation, making the cells more receptive to treatment. The increased ...