The following is a summary of “Survival impact of hypoxia-inducible factor-1 alpha (HIF-1α) in Nucleophosmin1 mutated acute myeloid leukemia,” published in the December 2024 issue of Hematology by ...

Fibrosis is the outcome of any abnormal tissue repair process that results in normal tissue replacement with scar tissue, leading to persistent tissue damage and cellular injury. During the process of ...

Fig 1. Targeting the nonimmune stromal compartment of the PDAC TME. A summary of the current stromal-targeting therapies in PDAC, including (a) degradation of HA in ECM with hyaluronidase; (b) ...

PHD has been shown to play a critical role in regulating the stability and transcriptional activity of hypoxia-inducible factor-1α (HIF-1α ... the best of its PHD inhibitors into the clinic ...

NK cells’ metabolism, proliferation, survival, and cytotoxic function are all impacted by intracellular checkpoint molecules such as FBP-1, EZH2, CIS, TIPE2, and HIF-1α, which significantly ...

hiroshima-u.ac.jp Background and aim There is a growing body of evidence demonstrating that plasminogen activator inhibitor-1 (PAI-1) is involved in the progression of pulmonary fibrosis. In fact, PAI ...

Researchers from the University of Michigan Medical School and MDI Therapeutics Inc. recently presented preclinical data for MDI-2517, a novel potent inhibitor of plasminogen activator inhibitor 1 ...

1 Department of Spine Surgery and Innovative Laboratory of Orthopedics ... Normal CESC-derived exosomes (N-exos) can effectively activate the PI3K/AKT signaling pathway in NPCs and HIF-1α/Wnt ...

These effects in stromal cells include altered integrin expression patterns, increased expression levels of cyclo-oxygenase 2, vascular endothelial factor A (VEGF-A), collagen I and hypoxia-inducible ...