These effects in stromal cells include altered integrin expression patterns, increased expression levels of cyclo-oxygenase 2, vascular endothelial factor A (VEGF-A), collagen I and hypoxia-inducible ...

Of interest, HIF-1 is among the primary genes involved in the homoeostatic process, which can increase vascularisation in hypoxic areas, such as localised ischaemia and tumours. The production of BNP ...

Additional doses of 1.25 mg may be given at six-hour intervals. For patients with a creatinine clearance of ≤30 mL/min (serum creatinine concentration of ≥3 mg/dL), the starting dose should be ...

Summary Apixaban is an oral, direct, selective factor Xa inhibitor with a rapid onset of action. It has a plasma elimination half-life of 12 hours and has been administered in a twice-daily dosing ...

New drugs for immunological and inflammatory diseases feature prominently among new product launches this year that could top $1 billion in ... first drug in the HIF-PHI inhibitor class to reach ...