Risk in Women With BRCA and Other Mutations The 10-year cumulative risk of developing contralateral breast cancer is 33% for premenopausal people who have a BRCA1 mutation, 27% for BRCA2, and 13% for ...
The difference between hereditary (germline) and acquired (somatic) gene mutations in cancer can lead to much confusion. This is especially true if you’re hearing about genetic testing for a genetic ...
Real-World Treatment Patterns After Discontinuation of Venetoclax or BTKis in the Frontline Setting Among Older Adults With Chronic Lymphocytic Leukemia Indications for and implications of germline ...
Research has also identified other mutations, which may also increase the risk of breast cancer development. These include changes in the PALB2, ATM, CHEK2, KRAS, CDH1, TP53, PTEN, and numerous other ...
Loss-of-function mutations in checkpoint kinase 2 (CHEK2) have been reported to delay menopause and elevate the mosaic loss of the Y chromosome. Further, later age at menopause has been associated ...
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