另一种药物Fisetin作为一种天然黄酮类化合物，也表现出了广泛的抗衰老潜力。它不仅降低了老年小鼠血浆中IL-17A和其他促炎蛋白的水平，还在雌性小鼠中显著提高了CA13等代谢相关蛋白的表达。这种双向调控的效果表明，Fisetin可能不仅能缓解衰老的 ...

Mayo Clinic researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence ...

【导读】细胞衰老是一种衰老机制，其特点是细胞周期停滞和衰老相关分泌表型（SASP）。临床前研究表明，针对衰老细胞存活途径的衰老溶解药物，可以对抗多个器官的衰老相关病症。不同的衰老分解药物在体内改变衰老和衰老生物标志物的比较功效，尚未得到证实。2024 ...

The body's ability to respond to cellular stress is a critical mechanism for maintaining health. When cells undergo damage or ...

A new study led by researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) found ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science ...

Senescence is the final act in a leaf’s life, when it changes color and falls from the tree. Trees need frosty temperatures ...

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget 10: 8226-43, 2015 Abbas Manji G, Singer S, Koff A, and Schwartz ...

These initial results suggest that individuals with SCD have a significantly higher cellular senescence burden which may ...