This discovery provides insights into a key RNA modification, N6-methyladenosine (m6A), which is linked to numerous biological processes and diseases, including cancer. mRNA is a type of RNA that ...

Researchers discovered that the mRNA modification m6A triggers rapid degradation, regulating protein production. This ...

a. 18097 inhibits FTO to promote substrate mRNAs m6A level in breast cancer. b. HUHS015 disturbs ALKBH3 functioning as prostate cancer antigen 1. c. R-2HG prevents FTO removing m6A from MYC/CEBPα ...

Figure 3. Drosophila m6A pathway. (A) m6A writers and readers. (B) Mapping of m6A modifications (miCLIP track) relative to mRNA-seq identifies extensive modification in the intronic regions (CIMS, ...

"m6A is interesting for science because this modification is often altered in people who suffer from metabolic disorders, cancer or heart disease," explains bioinformatician Kathi Zarnack.

By blocking METTL3, a protein that regulates m6A RNA modification, the researchers were able to promote cancer cell differentiation, making the cells more receptive to treatment. The increased ...

Reports have shown that the epigenetic modification N 6-methyladenosine (m6A) on mRNA is associated with female reproductive diseases and pregnancy-related conditions, such as preeclampsia ...

A major tool in these studies is single-cell epitranscriptomics, which studies RNA modifications like m6A methylation ... especially in diseases like cancer. "The implications of SigRM reach ...

A major tool in these studies is single-cell epitranscriptomics, which studies RNA modifications like m6A methylation ... especially in diseases like cancer. “The implications of SigRM reach ...