For experiments investigating post-transcriptional regulation, I use the Drosophila insulin-like receptor pathway and the cellular response to insulin. Transcriptional control of gene expression The ...

Dopamine receptors bind dopamine, insulin receptors bind insulin ... a sequence of molecular switches to internal signaling pathways. Membrane receptors fall into three major classes: G-protein ...

In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway.

Prof. Heiko Lickert is the director of the Institute of Diabetes and Regeneration Research at Helmholtz Munich, professor at the Technical University of Munich (TUM), and member of the German ...

Together with his team, they discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both Inceptor and the insulin receptor are located on the surface ...

The insulin-inhibitory receptor ‘Inceptor’ binds insulin and directs its breakdown within beta cells, a new study has shown. This comes after the same team led by Professor Heiko Lickert found that ...

In addition, there is evidence that in type 2 diabetes, the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and ...

For the organism it is important to replenish internal energy storages selectively and selective appetite for nutrients might uncover internal energy requirements. How is the selective uptake of a ...

Scientists discover how the Fas-p53 pathway sabotages energy metabolism, offering new hope for tackling obesity and improving insulin sensitivity ... Cell Surface Death Receptor (FAS) in ...