Our research aims to identify the biological mechanisms that cause and drive triple negative forms of breast cancer (which make up around 15-20% of all diagnosed breast cancers). Professor Tutt's ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

How would you identify the protein that serves as a ... Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

In future, fine-tuning of the test might help to better identify and characterize the DNA damage that it measures. Additional steps to decondense the highly compacted sperm DNA, and to distinguish ...

They assessed these responses after ionizing radiation or DNA-damaging agents ... of variant influences on the DNA damage ...

Enzymes called DNA damage response kinases and tubulin acetyltransferase ... "There is a huge effort to identify new ...

The primary end point was objective response rate, and secondary end points included progression-free survival ... Cohort B included patients with confirmed histologic diagnosis of malignancy and ...

In September, Rakovina initiated a collaboration with Variational AI to use their Enki™ platform to discover novel kinase inhibitors. This partnership is focused on developing new therapies that could ...

Rakovina Therapeutics Inc., a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response technologies, has announced the closing of a $3.0 million private ...