The paper is titled "The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia." The enzymes can already be blocked ...

PHD has been shown to play a critical role in regulating the stability and transcriptional activity of hypoxia-inducible factor-1α (HIF-1α ... the best of its PHD inhibitors into the clinic ...

Moreover, other inhibitory receptors like CD94/NKG2A, PD-1, TIGIT, and TIM-3 ... activity of tumor-infiltrating NK cells. Inhibition of HIF-1α in NK cells may improve treatment of solid tumors.

Inhibition of proangiogenic factors, such as VEGF and HIF-1α. Normalization ... a reduction in VEGF and HIF-1α proangiogenic factors, and an increase in TSP-1 antiangiogenic factors.