Our research group studies the mechanisms of protein trafficking and quality control at the endoplasmic reticulum (ER) in mammalian cells. A major focus of research is on the COPII protein machinery ...

Due to its dual role in adaptive immune responses, modulation of endoplasmic reticulum aminopeptidase 1 (ERAP1) is considered a potential strategy to both boost cancer immunotherapies or reduce ...

"We showed that these proteins are similar to the highly abundant reticulon proteins, which are known to tubulate endoplasmic reticulum membrane," said Joshi. "We published these findings in ...

We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic reticulum proteins involved in cellular stress signalling, including in ...

Protein synthesis in eukaryotic cells found in plants, animals, and fungi involves more than just the straightforward ...

We focus on studying stroke, Parkinson’s disease, and motivation, with the ultimate long-term goal being to develop disease-modifying therapies. We have a curiosity about endoplasmic reticulum ...

BiPER Therapeutics raises €800,000 in bridge funding to advance its first-in-class BiP-inhibitor for gastrointestinal cancers to clinical trialsNon-dilutive bridge funding marks important milestone ...