The NMR and Drug Metabolism Core has developed rapid and efficient approaches to investigate metabolism, metabolic stability, pharmacokinetics (PK), and chemical structure identification of small ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

Pharmacokinetics (PK) and pharmacodynamics (PD) are essential in drug development, providing critical insights into the ...

The past 10 years or so have witnessed a dramatic change in the way in which drugs are discovered and developed. New target identification has been impacted by what has been termed the "genome ...

The NMR and Drug Metabolism Core at Baylor College of Medicine offers tools to support the discovery, synthesis, screening, optimization, metabolism and pharmacokinetics of small molecule ligands or ...

Individuals respond to drugs in different ways, and it appears that each person’s microbiome may play a significant role in how drugs are absorbed and metabolized by the body. I have followed ...

A MedUni Vienna study has identified a new approach to the drug treatment of metabolic liver diseases. In an experimental ...

Prof Pontzer said it could help reveal whether cancers spread differently as the metabolism changes and if drug doses could be adjusted during different phases. And there is even discussion about ...

Cancer treatment has advanced significantly in recent years, yet drug resistance remains a major obstacle, particularly in aggressive cancer types. Drug-resistant cancer cells often undergo metabolic ...

The team changed drug delivery tactics, starting with a high dose and tapering off—and stopping after four weeks. "This way, ...

Despite such growth, there remains a set of complex hurdles associated with drug development for rare metabolic diseases. Inborn Errors of Metabolism Drug Development 2020 is dedicated to ...

Drug-induced liver injury (DILI ... as they discuss the current understanding of the mechanisms that contribute to DILI and how advances in reactive metabolism trapping have improved detection ...