The NMR and Drug Metabolism Core has developed rapid and efficient approaches to investigate metabolism, metabolic stability, pharmacokinetics (PK), and chemical structure identification of small ...

The past 10 years or so have witnessed a dramatic change in the way in which drugs are discovered and developed. New target identification has been impacted by what has been termed the "genome ...

Pharmacokinetics (PK) and pharmacodynamics (PD) are essential in drug development, providing critical insights into the ...

Individuals respond to drugs in different ways, and it appears that each person’s microbiome may play a significant role in how drugs are absorbed and metabolized by the body. I have followed ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

The NMR and Drug Metabolism Core at Baylor College of Medicine offers tools to support the discovery, synthesis, screening, optimization, metabolism and pharmacokinetics of small molecule ligands or ...

Cancer treatment has advanced significantly in recent years, yet drug resistance remains a major obstacle, particularly in aggressive cancer types. Drug-resistant cancer cells often undergo metabolic ...

A MedUni Vienna study has identified a new approach to the drug treatment of metabolic liver diseases. In an experimental ...

Despite such growth, there remains a set of complex hurdles associated with drug development for rare metabolic diseases. Inborn Errors of Metabolism Drug Development 2020 is dedicated to ...

Medicilon, a leading preclinical contract research organization (CRO), has named Dr. Lilly Xu as its new Chief Technology ...

The team changed drug delivery tactics, starting with a high dose and tapering off—and stopping after four weeks. "This way, ...

as they discuss the current understanding of the mechanisms that contribute to DILI and how advances in reactive metabolism trapping have improved detection capabilities. During this special 1.5 hour ...