so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different circumstances. For many of these pathways, scientists have long known ...

How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the ...

Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

The mammalian DNA repair process has evolved over time into a number of complex pathways to cope with all of the alterations that can occur to the structure of DNA. The past 30 years have seen a ...

It will focus on the relationship between a given neurological disorder and the type of DNA repair pathway that is compromised, with special emphasis given to oxidative DNA damage and its repair.

The Arnoult lab focuses on genome stability, DNA repair and telomere biology. We study the different types of pathways that cells use to repair DNA double strand breaks, and how telomeres escape these ...

More than 60 years ago, we provided the first conclusive evidence that the fundamental cause of cancer is damage to our DNA. The DNA damage response is a series of pathways used by cells to repair ...

Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new research.

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used ...

In addition, we study an ancient yet error-prone DNA repair pathway, termed micro-homology mediated end-joining, and focus on polymerase theta, a key enzyme underlying mutagenic repair. Lastly, we ...