▎药明康德内容团队编辑（来源：北京大学）DNA损伤修复在维持基因组稳定性中发挥关键作用，其相关基因的突变可能危害基因组完整性，并增加癌症发生的风险。顺铂（Cisplatin）和电离辐射（IR）等DNA损伤药物被广泛用于肿瘤治疗，但临床治疗中不断发现病 ...

基于团队此前开发的赖氨酸功能位点筛选策略和基因敲除策略，他们分别利用腺嘌呤碱基编辑器（ABE）和胞嘧啶碱基编辑器（CBE），对全基因组范围内的赖氨酸位点或基因进行靶向编辑，实现赖氨酸位点突变或敲除基因。随后在人类视网膜色素上皮细胞系（RPE1）中进行 ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the ...

The input of the DeepTXsolver is the parameters of the mechanism model, and the output is the corresponding stationary distribution solution of the model. The input to the DeepTXinferrer is the ...

The primary end point was objective response rate, and secondary end points included progression-free survival ... Cohort B included patients with confirmed histologic diagnosis of malignancy and ...

Professor Tutt's group is interested in therapy development for BRCA1/2 associated and Triple Negative forms of breast cancer, based on DNA Damage Repair (DDR) and in particular Homologous ...

In September, Rakovina initiated a collaboration with Variational AI to use their Enki™ platform to discover novel kinase inhibitors. This partnership is focused on developing new therapies that could ...

DNA replication, repair, and damage response, collectively called the 3Rs, support genome stability and faithful genetic inheritance. Proteins involved in the 3Rs are genome guardians that prevent a ...