▎药明康德内容团队编辑（来源：北京大学）DNA损伤修复在维持基因组稳定性中发挥关键作用，其相关基因的突变可能危害基因组完整性，并增加癌症发生的风险。顺铂（Cisplatin）和电离辐射（IR）等DNA损伤药物被广泛用于肿瘤治疗，但临床治疗中不断发现病 ...

【导读】保持基因组稳定性，对细胞平衡至关重要。在这项研究中，团队将CRISPR介导的碱基编辑与集合筛选技术相结合，确定了赖氨酸残基和蛋白质编码基因的大量突变。这些赖氨酸残基和基因的缺失，导致了对DNA损伤剂的敏感性或抗性。2024年12月10日，北京 ...

基于团队此前开发的赖氨酸功能位点筛选策略和基因敲除策略，他们分别利用腺嘌呤碱基编辑器（ABE）和胞嘧啶碱基编辑器（CBE），对全基因组范围内的赖氨酸位点或基因进行靶向编辑，实现赖氨酸位点突变或敲除基因。随后在人类视网膜色素上皮细胞系（RPE1）中进行 ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the ...

The input of the DeepTXsolver is the parameters of the mechanism model, and the output is the corresponding stationary distribution solution of the model. The input to the DeepTXinferrer is the ...

The primary end point was objective response rate, and secondary end points included progression-free survival ... Cohort B included patients with confirmed histologic diagnosis of malignancy and ...

In September, Rakovina initiated a collaboration with Variational AI to use their Enki™ platform to discover novel kinase inhibitors. This partnership is focused on developing new therapies that could ...

DNA replication, repair, and damage response, collectively called the 3Rs, support genome stability and faithful genetic inheritance. Proteins involved in the 3Rs are genome guardians that prevent a ...

The study highlights how EV-DNA packaging influences immune responses and its promise as a biomarker for assessing colorectal ...