Moore, C. W. et al. DNA damage-inducible and RAD52-independent repair of DNA double-strand breaks in Saccharomyces cerevisiae. Genetics 154, 1085–1099 (2000). Myung, K. & Kolodner, R.

DNA is susceptible to damage caused by errors committed during replication and by environmental ... Nicks are potentially deleterious DNA lesions that, if not corrected, may give rise to lethal double ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

These mechanisms can detect and correct different types of DNA damage, such as base mismatches, single-strand breaks, and double-strand breaks. DNA repair is essential for preventing the accumulation ...

More information: DNA double-strand break–capturing nuclear envelope tubules drive DNA repair, Nature Structural & Molecular ...

Almost all of these mosaic mutations begin as nucleotide mismatches or damage in only one of the two strands of the DNA prior to becoming double-strand mutations if unrepaired or misrepaired. However, ...

Abbreviations: BER, base excision repair; DSB, double-stand break; ERCC2, xeroderma pigmentosum complementing protein D; ERCC3, xeroderma pigmentosum complementing ...

When a cell divides, it makes a copy of its DNA instructions for the new cell. The twisted double strand structure -- the famed double helix -- unwinds and the strands separate. The nucleotides (A ...

In the double helix structure of DNA ... including thymine, to the growing new strand. Mutations involving thymine can occur during DNA replication or as a result of DNA damage. Some common ...