The sugar-phosphate backbone forms the structural framework of nucleic acids, including DNA and RNA. This backbone is composed of alternating sugar and phosphate groups, and defines directionality ...

plays a central role in DNA repair by cleaving the DNA backbone 5′ of AP sites that result from removal of damaged bases. New structural findings on APE1–DNA cocrystals provide insights into ...

internally crosslinked by the covalent backbone of a single DNA molecule. The spontaneous formation of well-defined ...