Nature5 年
Cdc42 has a key role in modulating osteoclast formation and function
By contrast, gain-of-function mice (in which Cdc42 was basally active, owing to deletion of Cdc42Gap, a protein that inactivates Cdc42) were osteoporotic. In vitro experiments showed that Cdc42 ...
Nature1 个月
Bending around the BAR
Shimada et al. determined the structures of the related F-BAR domains from formin-binding protein-17 (FBP17) and Cdc42-interacting protein-4 (CIP4). Compared with the N-BAR domain, the F-BAR ...
Interesting Engineering on MSN1 个月
Berry-flavored vapes paralyze lung immune cells more than non-flavored: Study
The study reveals that AMs utilize cell division control protein 42 (CDC42)-mediated actin polymerization pathways for their ...
mskcc.org6 年
Mechanisms of BCG induced anti-tumor immunity
We have established that the uptake of BCG by bladder cancer cells is through macropinocytosis rather than phagocytosis. Entry of BCG into bladder cancer cells is dependent on Rac1, Cdc42, and the ...
Boston College2 年
Biology Department Faculty
2016. Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5. eLife, pii:e14216. 12. Wei B, Hercyk BS§, Mattson N, Mohammadi A#, Rich ...