PD-1是CD28家族的一员，在多种免疫细胞中表达，特别是外周组织中活化的CD8+T细胞、CD4+T细胞和B细胞中[2]。PD-1有两个结合配体，PD-L1(B7-H1或CD274 ...

gondii are unstable. Although the host contributes to this instability via expression of down-regulatory proteins (PD-1) on the surface of the CD8 T cells (Figure 2), whether and how the parasite ...

【导读】阻断免疫检查点PD-1和TIGIT，已在小鼠肿瘤模型和人类癌症患者中显示出活性。虽然这些共抑制受体可以通过调节与之相关的共刺激受体CD28和CD226来限制CD8 ...

“PDC*lung01 in combination with anti-PD-1 showed a very promising and durable ... 56% of patients exhibited tumor antigen-specific CD8+ T-cell responses, with measurable expansions of anti ...