located from exons 2 to 5. Sequence homology of this domain to a group of genes encoding proteins with DNA binding functions suggested that the BRCA1 protein might play a role in regulation of ...

Krainer and Cartegni fused a synthetic RS domain to an antisense fragment that binds to specific exons. They tested the ESSENCE concept first in the breast cancer 1, early onset gene (BRCA1), in ...

For cancer-suppressor genes like BRCA1, researchers have long hypothesized that a single healthy copy could still guard against tumor development. Yet women with one harmful BRCA1 mutation are far ...