Alois Alzheimer first imaged amyloid plaques in 1906 by examining dead tissue under the microscope, but their clinical significance has remained undetermined. Now, nearly a century later ...

Amyloid plaques comprising tangled fibrils of misfolded proteins are well-known drivers of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, but they are also present ...

but disease hallmarks include the accumulation of amyloid-beta plaques and hyperphosphorylated tau neurofibrillary tangles. The former is known to deposit earlier and influences the aggregation of ...

The drugs attack so-called amyloid plaques in the brain ... non-quantitative evidence of amyloid deposits in the brain. Method number 2 involves a technique for imaging the brain called positron ...

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

This study confirmed its link to amyloid plaque formation but also showed ... For instance, the BIN1 gene was linked to α-synuclein deposits, a feature of Parkinson's disease and dementia with ...

A central symptom of AD is accumulating plaques containing β-amyloid causing synaptic failure, leading to neuronal death. Thanks to the advent of induced pluripotent stem cells (iPSCs), the ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Higher levels of visceral fat were correlated with more amyloid plaque in the brains of cognitively normal individuals ...

which checks blood levels for a combination of phosphorylated Tau-181 and apolipoprotein E4—could be counted on to help identify patients who were unlikely to have the amyloid plaque deposits ...

A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of ...