The gene defective in this disorder, ATM (for AT-mutated), encodes a protein ... It has been suggested that pATM acts as part of a complex that senses DNA damage and in particular DNA double ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Led by Haichao Zhao, PhD, in the Yan Lab at UNC Charlotte, the new research shows how ATM-mediated signaling is induced by DNA single-strand breaks (SSBs) for DNA damage repair – illuminating ...